Taller women prone to get cancer, big study finds

in Cancer

The higher a post-menopausal woman is, the more her possibility for developing cancer, based on a brand new, significant study of American women. Similar results have been found in other Western populations, including in Canada and the Great Britain, and in Asia.

“There had been many previous reports but there hadn’t been much performed in North America” states Dr. Thomas E. Rohan, chair and professor of epidemiology and citizenry health at Albert Einstein College of Medicine in the Bronx, Ny. He is the senior author of the paper printed Thursday in Cancer Epidemiology, Biomarkers & Prevention, a diary of the American Association for Cancer Research.

“We unearthed that there clearly was a solid, significant relationship between height and cancer risk, both for all cancers combined and for many unique cancer sites” says Rohan. These certain cancer internet sites are melanoma, colon, butt, bust, endometrium, ovary, elimination, thyroid, colorectum and multiple myeloma.

Each 10 centimeter - about 4-inch - increase in height is connected with a 13% increase in total cancer risk, based on his group’s examination of 144701 females aged 50 to 79 participating in the Women’s Health Initiative, a major, long-term research program founded by the National Institutes of Health in 1991.

Rohan and his colleagues modified for other known risk factors, including body weight, ethnicity, smoking, liquor consumption, cancer screening, and hormone therapy use. The truth is, the analysis is one of the more detailed of its kind to verify that being tall independently lifts a person’s likelihood of developing cancer.

“This study is in women, our study was in women, nevertheless when we looked at reports of men as well, it's very similar” says Dr. Jane Green, a clinical epidemiologist at the University of Oxford, England and the lead writer of the largest study to date of the link between height and cancer.

That link “doesn’t appear to rely on when the study was done, or what the population was, or what the height of the population was on average, or the ethnicity of the population” says Green. “It may suggest some thing interesting about how cancer develops in general”

Researchers say they don't know precisely why height is connected with cancer risk. “We speculate” says Rohan.

Being large may raise a person’s odds of developing cancer mainly because taller folks have more cells, and while they divide, which can lead to cancer, state researchers cells can mutate. But that reason is “not actually of further technological interest” says Green as it doesn’t give any insight into the actual means of how cancer develops.

Alternatively, researchers focus on other possible factors, including genetics. “Eighty percent of the difference tall in Western communities is estimated to be dependant on genetics” based on today’s study. These genes may have something regarding cancer development at the same time.

But adult height can also be dependant on setting. “An obvious candidate is nourishment in early life” says Rohan. “There has been a secular trend in the last century roughly of improving adult height, and that has been caused by improvements in care and to improvement in early childhood nutrition as well”

Adult height is associated with drinking more milk, for instance, which will be associated with higher circulating levels of so-called insulin-like growth factor, or IGF-I. IGF-I helps kiddies develop, but studies have shown it is also connected with increased threat of certain cancers.

Rohan wish to see upcoming studies examine the genes connected with height to see when there is a cancer link. Additionally, he says, research studies which have recruited individuals at a young age may fundamentally “help us to understand whether nutrition in early life is adding to cancer risk”

In the meantime, tall people should not concern yourself with their cancer possibility, says Green. The relationship of height with cancer risk is substantial but “modest” she says, and being large really has a lower risk of some other diseases, such as for example heart disease and stroke.

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Taller women prone to get cancer, big study finds

This article was published on 2013/08/01